Penetration coefficient dmso
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Abbreviations: DMSO: dimethylsulfoxide. Kp: permeability coefficient ability increased, with a permeability coefficient greater than that from water being achieved.
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penetration of a solute through any given membrane: 1) the diffusion coefficient .
The addition of 50% DMSO resulted in a comparable lidocaine . apparent permeability coefficient in the microneedle pretreated skin samples.
Description:The authors discuss the history, chemistry, and clinical utility of one such agent—dimethyl sulfoxide DMSO —a common, controversial substance with a storied past. The amount of lidocaine in the receptor fluid was determined by UV—VIS high-performance liquid chromatography. The most frequent outcome measures were reduction of erythema and rapid healing of ulcers, along with decreased signs of inflammation, such as rubor, dolor, calor, and tumor. Alteration of membrane thickness is less practical for drug delivery it is difficult to conceive of nontoxic agents that could reversibly decrease the thickness of the stratum corneum , so most penetration agents, including DMSO, attempt to reversibly alter principals 1 to 3. Prevention of cytotoxic drug induced skin ulcers with dimethyl sulfoxide DMSO and alpha-tocopherole. There is some evidence to suggest that DMSO can increase diffusion through the stratum corneum by disruption of the barrier function. DMSO may also play a role in partitioning as well by forming solvent microenvironments within the tissue that can effectively extract solute from vehicle.